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KMID : 0624620170500020079
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BMB Reports
2017 Volume.50 No. 2 p.79 ~ p.84
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Human adipose-derived mesenchymal stem cell spheroids improve recovery in a mouse model of elastase-induced emphysema
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Cho Ryeon-Jin
Kim You-Sun
Kim Ji-Young
Oh Yeon-Mok
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Abstract
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Emphysema, a pathologic component of the chronic obstructive pulmonary disease, causes irreversible destruction of lung. Many researchers have reported that mesenchymal stem cells can regenerate lung tissue after emphysema. We evaluated if spheroid human adipose-derived mesenchymal stem cells (ASCs) showed greater regenerative effects than dissociated ASCs in mice with elastase-induced emphysema. ASCs were administered via an intrapleural route. Mice injected with spheroid ASCs showed improved regeneration of lung tissues, increased expression of growth factors such as fibroblast growth factor-2 (FGF2) and hepatocyte growth factor (HGF), and a reduction in proteases with an induction of protease inhibitors when compared with mice injected with dissociated ASCs. Our findings indicate that spheroid ASCs show better regeneration of lung tissues than dissociated ACSs in mice with elastase-induced emphysema.
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KEYWORD
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Adipose-derived mesenchymal stem cells, Chronic obstructive pulmonary disease, Regeneration, Spheroid cultures
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